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Evaluation of CD4 Cell Progression Among HIV Infected Children Initiating ART: A Case of Adama Referral Hospital and Medical College, Ethiopia

Received: 12 December 2019     Accepted: 23 December 2019     Published: 8 April 2020
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Abstract

Human immune deficiency virus (HIV) is a major cause of infant and childhood mortality and morbidity; without treatment about 50% of them will succumb to HIV/AIDS before the age of two years. HIV infected children should start ART in order to reduce AIDS related morbidity and mortality, or to improve their survival time. Effective therapies and reduced AIDS related morbidity and mortality have shifted the focus in pediatric human immune deficiency virus (HIV) from minimizing short-term disease progression to maintaining optimal long-term health. The main purpose of this study was to evaluate the predictors of longitudinal CD4 cell progression of HIV infected children who were under ART. The study considered a cohort of 201 HIV infected children who were aged 15 years or younger and those were on ART from October 1, 2013 to March 30, 2017 at Adama Referral Hospital and Medical College. To analyze the data we employed exploratory data analysis and linear mixed effect model. The result from linear mixed effect model reviled that observation time, age, WHO clinical stage, history of TB, and functional status had significantly associated with mean change in the square root of CD4 cell count, and they are the predictor of longitudinal CD4 cell change.

Published in Pathology and Laboratory Medicine (Volume 4, Issue 1)
DOI 10.11648/j.plm.20200401.11
Page(s) 1-6
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

CD4 Cell Count, HIV/AIDS, Linear Mixed Effect Model

References
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[4] Ethiopian Public Health Institute (EPHI), Federal Ministry of Health. HIV Related Estimates and Projections for Ethiopia July, 2017, Addis Ababa, Ethiopia.
[5] Ashir, G. M., Rabasa, A. I., Gofama, M. M., Elechi, H. A., & Lawan, B. M. (2014). Clinical Staging of HIV Infection as a Surrogate for CD4 Count in HIV-Infected Children. West African Journal Of Medicine: 29 (5).
[6] Welch, S. B., & Gibb, D. (2014). When should children with HIV infection be started on antiretroviral therapy. PLoS medicine, 5 (3), e73.
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[8] Mellors, JW., Munoz, A., Giorgi, JV., Margolick, JB., Tassoni, CJ., & Gupta, P. (1997). Plasma viral load and CD4z lymphocytes as prognostic markers of HIV-1 infection. Ann Intern Med 1997; 126: 946–54.
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[13] Verbeke, G., & Molenberghs, G. (2000). Linear Mixed Models for Longitudinal Data. new York: Springer.
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[16] Laird, N. M., & Ware, J. H. (1982). Random-effects models for longitudinal data. Biometrics, 38 (4), 963-974.
[17] Little, R. J. A. (2006). Modeling the drop out mechanism in repeated measures studies. Journal of the American Statistical Association, 90 (431): 1112-1121.
[18] Marie-Quitterie, P., Joanna, L., Victor, M., Andrew P., Kusum, N., & Addy, K. (2013). Predicting Patterns of Long-Term CD4 Reconstitution in HIV-Infected Children Starting Antiretroviral Therapy in Sub-Saharan Africa: A Cohort-Based Modelling Study: PLoS Med 10 (10): e1001542.
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  • APA Style

    Tayu Nigusie Abebe. (2020). Evaluation of CD4 Cell Progression Among HIV Infected Children Initiating ART: A Case of Adama Referral Hospital and Medical College, Ethiopia. Pathology and Laboratory Medicine, 4(1), 1-6. https://doi.org/10.11648/j.plm.20200401.11

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    Tayu Nigusie Abebe. Evaluation of CD4 Cell Progression Among HIV Infected Children Initiating ART: A Case of Adama Referral Hospital and Medical College, Ethiopia. Pathol. Lab. Med. 2020, 4(1), 1-6. doi: 10.11648/j.plm.20200401.11

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    AMA Style

    Tayu Nigusie Abebe. Evaluation of CD4 Cell Progression Among HIV Infected Children Initiating ART: A Case of Adama Referral Hospital and Medical College, Ethiopia. Pathol Lab Med. 2020;4(1):1-6. doi: 10.11648/j.plm.20200401.11

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  • @article{10.11648/j.plm.20200401.11,
      author = {Tayu Nigusie Abebe},
      title = {Evaluation of CD4 Cell Progression Among HIV Infected Children Initiating ART: A Case of Adama Referral Hospital and Medical College, Ethiopia},
      journal = {Pathology and Laboratory Medicine},
      volume = {4},
      number = {1},
      pages = {1-6},
      doi = {10.11648/j.plm.20200401.11},
      url = {https://doi.org/10.11648/j.plm.20200401.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.plm.20200401.11},
      abstract = {Human immune deficiency virus (HIV) is a major cause of infant and childhood mortality and morbidity; without treatment about 50% of them will succumb to HIV/AIDS before the age of two years. HIV infected children should start ART in order to reduce AIDS related morbidity and mortality, or to improve their survival time. Effective therapies and reduced AIDS related morbidity and mortality have shifted the focus in pediatric human immune deficiency virus (HIV) from minimizing short-term disease progression to maintaining optimal long-term health. The main purpose of this study was to evaluate the predictors of longitudinal CD4 cell progression of HIV infected children who were under ART. The study considered a cohort of 201 HIV infected children who were aged 15 years or younger and those were on ART from October 1, 2013 to March 30, 2017 at Adama Referral Hospital and Medical College. To analyze the data we employed exploratory data analysis and linear mixed effect model. The result from linear mixed effect model reviled that observation time, age, WHO clinical stage, history of TB, and functional status had significantly associated with mean change in the square root of CD4 cell count, and they are the predictor of longitudinal CD4 cell change.},
     year = {2020}
    }
    

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    AB  - Human immune deficiency virus (HIV) is a major cause of infant and childhood mortality and morbidity; without treatment about 50% of them will succumb to HIV/AIDS before the age of two years. HIV infected children should start ART in order to reduce AIDS related morbidity and mortality, or to improve their survival time. Effective therapies and reduced AIDS related morbidity and mortality have shifted the focus in pediatric human immune deficiency virus (HIV) from minimizing short-term disease progression to maintaining optimal long-term health. The main purpose of this study was to evaluate the predictors of longitudinal CD4 cell progression of HIV infected children who were under ART. The study considered a cohort of 201 HIV infected children who were aged 15 years or younger and those were on ART from October 1, 2013 to March 30, 2017 at Adama Referral Hospital and Medical College. To analyze the data we employed exploratory data analysis and linear mixed effect model. The result from linear mixed effect model reviled that observation time, age, WHO clinical stage, history of TB, and functional status had significantly associated with mean change in the square root of CD4 cell count, and they are the predictor of longitudinal CD4 cell change.
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Author Information
  • Department of Statistics, Bule Hora University, Bule Hora, Ethiopia

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